BIOSYNTHESIS OF RARE 20(R)-PROTOPANAXADIOL/PROTOPANAXATRIOL TYPE GINSENOSIDES THROUGH ESCHERICHIA COLI ENGINEERED WITH URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE GENES

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng.Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize.The present study provides an approach to

Duchenne muscular dystrophy (DMD) is a lethal, X-linked disease that causes severe loss of muscle mass and function in young children.Promising therapies for DMD are being developed, but the long lead times required when using clinical outcome measures are hindering progress.This progress would be facilitated by robust molecular biomarkers in biofl

Testicular germ Side Cover cell tumors (TGCTs) are unique amongst solid tumors in terms of the high cure rates using chemotherapy for metastatic disease.Nevertheless, TGCTs still kill approximately 400 men per year, at a median age of 30 years, in the United States.This young age of mortality dramatically amplifies the impact of these deaths for th

The current study explores the effects of physical spacing within mathematical expressions on student performance.A total of 2,152 students in 5th-12th grade were randomly assigned to one of four conditions within an online problem set, with terms in algebraic expressions spaced 1) neutrally, with no spaces in the expression, 2) congruent with the

In the period from 1945 to 1947, the new communist authorities sought to emphasize its legitimacy as much as possible, which was based on changes made during the liberation war and revolution.The war and revolution changes had a special place in the public discourse, being understood as a main tool for shaping historical awareness of young generati